Blar i forfatter "Struck, Eike Christopher"

Viser treff 1-3 av 3

    • The Endothelial Cell Response to Inflammation, the Functional Role of the Endothelial-enriched Protein KANK3 and the Adipose Tissue Transcriptome 

      Struck, Eike Christopher (Doctoral thesis; Doktorgradsavhandling, 2023-10-25)
      <p>A compilation of three complementary projects explores various facets of endothelial cell biology and transcriptomics, illuminating the intricate dynamics underlying cellular responses to specific stimuli across different tissues. <p>The first project examines how endothelial cells react to the inflammatory molecule tumour necrosis factor (TNF), by studying these cells over time after TNF ...

    • Global Transcriptome Analysis Reveals Distinct Phases of the Endothelial Response to TNF 

      Odeberg, Lynn Butler; Struck, Eike Christopher; Odeberg, Jacob Olof (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-29)
      The vascular endothelium acts as a dynamic interface between blood and tissue. TNF-α, a major regulator of inflammation, induces endothelial cell (EC) transcriptional changes, the overall response dynamics of which have not been fully elucidated. In the present study, we conducted an extended time-course analysis of the human EC response to TNF, from 30 min to 72 h. We identified regulated genes and ...

    • A human adipose tissue cell-type transcriptome atlas 

      Norreen-Thorsen, Marthe; Struck, Eike Christopher; Öling, Sofia Maria; Zwahlen, Martin; Von Feilitzen, Kalle; Odeberg, Jacob; Lindskog, Cecilia; Pontén, Fredrik; Uhlén, Mathias; Dusart, Philip James; Butler, Lynn (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-12)
      The importance of defining cell-type-specific genes is well acknowledged. Technological advances facilitate high-resolution sequencing of single cells, but practical challenges remain. Adipose tissue is composed primarily of adipocytes, large buoyant cells requiring extensive, artefact-generating processing for separation and analysis. Thus, adipocyte data are frequently absent from single-cell ...